Technology of High Pressure Hydraulic Fracturing and Rock Burst Prevention by Multi-layer Directional Slotting in Roof

In order to promote the controllable safety and efficiency of the hard roof in coal mines, this paper studies the multi-layer directional high pressure fracturing technology.The UDEC numerical simulation was used to study the kinetic and total energy release of the roof before and after directional hydraulic fracturing.The results show that the wei

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Getting insights into chemical composition and antiherpetic capability of jujube (Ziziphus jujuba mill.) drupes

Food plant diversity in bioactive compounds makes them an exploitable resource in the search for effective natural products to prevent or treat viral infections.Therefore, in the framework aimed at studying the antiviral properties of extractive mixtures from fruits (and their waste) grown in the Campania Region (Italy), jujube drupes (Zizyphus juj

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Small-Molecule PROTACs for Cancer Immunotherapy

Unsatisfactory physicochemical properties of macromolecular drugs seriously hinder their application in tumor immunotherapy.However, these problems can be effectively solved by small-molecule compounds.In the promising field of small-molecule drug development, proteolysis targeting chimera (PROTAC) offers a novel mode of action in the interactions

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